OTSU, JAPAN. Etretinate is a powerful drug used to treat skin disorders such as psoriasis. It can cause serious adverse effects when used in the regularly prescribed dose of about 1 mg/kg per day. Researchers at the Shiga University of Medical Science reported that a combination of eicosapentaenoic acid (EPA) and etretinate at a lower dose (0.3 - 0.5 mg/kg per day) works as well as the pure, high-dose and has significantly fewer side effects. Note that EPA in one of the main components in fish oil supplements.
GIESSEN, GERMANY. Psoriasis is a fairly common skin disease characterized by thick, silvery white scales surrounded by a red, inflamed border. Psoriasis is accompanied by high concentrations of arachidonic acid in the plaques and profound changes in the metabolism of eicosanoids leading to an increase in proinflammatory agents. It is known that eicosapentaenoic acid (EPA) counteracts the formation of these proinflammatory agents and some studies have shown that oral supplementation with fish oils benefits psoriasis patients.
SHEFFIELD, UNITED KINGDOM. Psoriasis is a relatively common skin disorder that affects between one and two per cent of the population. Itching, scaling, and erythema (abnormal flushing of the skin) are common features. Abnormal levels of leukotrienes (metabolites of arachidonic acid) are believed to be involved in the development and progression of the disorder. Eicosapentaenoic acid (EPA), a major component of fish oils, is known to dampen the adverse effects of leukotrienes and has been proven to have significant anti-inflammatory effects.